ANTI-SHB (N-TERM)

Not available outside of the UK & Ireland.

General description

SHB is an adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. It may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. It may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades, and may also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Immunogen

SHB (NP_003019, 15-49)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human SHB.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.