Anti-WNK1 (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

WNK is known to influence the activity of chloride transporters such as members of the SLC12 family. WNK1 regulates ion transportation in kidney and maintains chloride concentration in the neurons. It maintains cell volume during the change in the solute concentration. Osmotic stress and chloride depletion within the cell upregulates WNK1 (WNK lysine deficient protein kinase 1) expression. Mutations in WNK1 leads to familial hyperkalemic hypertension, a Mendelian disorder characterized with thiazide-sensitive hypertension, hyperkalemia, and normal glomerular filtration rate. It is associated with hereditary syndromes like renal disease pseudohypoaldosteronism type II (PHAII) and the neurological disease hereditary sensory neuropathy 2.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

WNK1 (WNK lysine deficient protein kinase 1) gene is mapped to human chromosome 12p13.33. The gene is ubiquitously expressed. The encoded protein contain an active PY motif of short linear proline sequence.

The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron.[supplied by OMIM]

Immunogen

WNK1 (Q9H4A3, 2266-2302)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human WNK1.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.