ANTI-OAS3 (C-TERM)

Not available outside of the UK & Ireland.

General description

OAS3 is an interferon inducible protein that belongs to the 2-5A synthetase family, may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2′,5′-oligoadenylate molecules. GTP can be an alternative substrate. OAS3 binds double-stranded RNA and polymerizes ATP into PPP(A2′P5′A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. The protein is present at high level in placenta trophoblast.

Immunogen

OAS3 (Q9Y6K5, 1060-1097)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human OAS3.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.