ANTI-ARL2 (N-TERM)

Not available outside of the UK & Ireland.

General description

ADP-ribosylation factors (ARFs) regulate intracellular vesicular membrane trafficking and stimulate a phospholipase D isoform. ARL (ADP-ribosylation like factor) proteins are very similar in sequence to ARFs. ARFs and ARF-like (ARL) proteins, which share sequence similarity with ARFs, form a subfamily of the Ras-related GTPase superfamily. ARL2 encodes a ubiquitiously expressed 184-amino acid predicted protein that is 76% identical to ARF1 and 40 to 45% identical to the Drosophila ARL proteins. Recombinant ARL2 binds to GTP rapidly but guanine nucleotide exchange does not require phospholipids, which is a characteristic of the ARF proteins.

Immunogen

ARL2 (NP_001658, 1-30)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ARL2.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.