Anti-Aurora-C (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

Not available outside of the UK & Ireland.

General description

Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.

Immunogen

AURORAC (Q9UQB9, 225-260)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human Aurora-C.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.