Anti-Drosophila Sumo (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

SUMO (small ubiquitin-related modifier) is significantly associated with various cellular and developmental processes in organisms that vary in complexity, from yeast to mammals. SUMO coordinates important developmental events during the early metazoan. SUMO carries out covalent modification of several targeted proteins that are necessary for embryonic development and many cellular processes including proteins involved in Ras signaling, cell cycle control, and embryonic patterning. SUMO is known to have wide functions in Drosophila life cycle including transcriptional regulation and immune response modulation. Reversible post-translational modification by SUMO regulates a number of transcription factors involved in cell proliferation, differentiation, and disease. Unlike ubiquitination, sumoylation does not lead to protein degradation, but might have an effect on their functions, localization and stability. SUMO promotes maximum ras-mediated MAP kinase activation. Sumoylation might stimulate or inhibit p53 activity.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

SMT3 (Small ubiquitin-related modifier) gene codes for a small ubiquitin-like modifier (SUMO) in Drosophila melanogaster. Drosophila Smt3 is 52% and 73% identical in sequence with human SUMO-1 and SUMO-2, respectively. The family of small ubiquitin-related proteins are covalently linked to lysine residues of protein substrates.

Covalent modification of target lysines by SUMO (small ubiquitin-like modifier) modulates processes such as protein localization, transcription, nuclear transport, mitosis, DNA replication and repair, signal transduction, and viral reproduction. SUMO does not seem to be involved in protein degradation and may in fact function as an antagonist of ubiquitin in the degradation process. In the development of Drosophila, SUMO plays a maternal role in anterior-posterior (A/P) polarity and patterning.

Immunogen

SUMO (NP_477411, 42-76)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Drosophila SUMO1.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.