Anti-Sirt6 (C-terminal) antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-Sirt6 (C-terminal) antibody has been used inimmunoblottingimmunofluorescencewestern blottingimmunohistochemistry

Biochem/physiol Actions

Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD⁺ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Sirtuin 6 (Sirt6) is a nuclear, chromatin-associated protein. Sirt6 is a member of Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.

Immunogen

synthetic peptide corresponding to amino acids 330-348 of human Sirt6.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.