Anti-phospho-Src (pTyr418) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution

Not available outside of the UK & Ireland.

Application

Anti-phospho-Src p(Tyr⁴¹⁸) antibody is suitable for use in western blot (1:1,000 using human platelets or mouse NIH3T3 cells). The product may also be used for immunoprecipitation (1:1000 using HEK293 or HEL cell lysates ).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Src is a proto-oncogene that regulates neuronal functions, such as nerve cell differentiation. The Src kinase family structurally comprises of SH2, SH3 and kinase domains, as well as a negative regulatory C-terminal tail. Src has also been implicated in functions such as cell growth, development and cell-cell interactions . Anti-phospho-Src p(Tyr⁴¹⁸) antibody is specific for human, mouse, rat and chicken Src (60 kDa).

Immunogen

synthetic phosphopeptide derived from the region of src that contains tyrosine 418, based on the sequence of human src.

The sequence is conserved in human, mouse, chicken and frog.

Physical form

Solution in Dulbecco′s phosphate-buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.