Anti-ICAD (ab2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

DNA fragmentation factor subunit α (DFFA) is a component of DNA fragmentation factor (DFF). It is mainly associated with apoptosis and genomic stability. Caspase-3-mediated cleavage of DFFA releases DFF40 (DNA fragmentation factor 40) which degrades chromosomal DNA. During menstruation, the apoptosis of endometrium cells is associated with DFFA. Its expression decreases after menopause. Silencing of DFFA increases doxorubicin effects in breast cancer cells.

General description

The gene DNA fragmentation factor subunit α (DFFA) is mapped to human chromosome 1p36.2. The encoded protein localizes to the chromatin fraction. It exist in association with DFF40, thereby forming a heterodimer. DFFA is popularly called as DFF45 (DNA fragmentation factor 45).

Immunogen

a peptide corresponding to amino acids 312-331 of mouse ICAD.

Linkage

The action of this antibody can be blocked using blocking peptide SBP2003.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide