Anti-potassium channel kv11.1

Not available outside of the UK & Ireland.

Application

Anti-Potassium channel K_v11.1 extracellular antibodies may be used in immunofluorescence microscopy . It may also be used for the detection of K_v11.1 by techniques such as immunocytochemistry, flow cytometry using live intact K562 (human chronic myelogenous leukemia) cells and western blotting.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The K⁺ channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM K⁺ channels based on the number of transmembrane domains. The voltage-gated Potassium or K_v channels belong to the 6 TM K⁺ channel family that also include other sub-types such as the hERG, KCNQ, and EAG channels. K_v11.1 belongs to the EAG family and facilitates the repolarization of normal action potential in heart muscles. Genetic alterations in K_v11.1 can cause heart disorders such as long QT syndrome, sudden cardiac death and arhythmias. K_v11.1 also regulates cell growth and hence may be studied as a target for cancer treatment. Anti-Potassium channel K_v11.1 extracellular antibodies are specific to K_v11.1.

Immunogen

peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human K_V11.1. This sequence has 11/16 residues identical in mouse and rat and has 15/16 residues identical in rabbit and dog.

Physical form

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.