Anti-Purinergic Receptor P2X3 antibody produced in rabbit, affinity isolated antibody, lyophilized powder

Not available outside of the UK & Ireland.

Application

Anti-Purinergic Receptor P2X3 antibody has been used in immunohistochemistry.

Biochem/physiol Actions

The P2X3 (purinergic receptor P2X 3) plays a major role in the transmission of pain. Inducing P2X3 generates a desensitizing transient response and initiating P2X2/3 creates a relatively persistent response. P2X3 decreases the sympathetic tone in SH rats.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The P2X3 (purinergic receptor P2X 3) receptor is expressed in primary afferent neurons. It is a subtype of P2X receptors family of ligand-gated ion channels, activated by extracellular ATP (adenosine triphosphate).

Immunogen

peptide (C)VEKQSTDSGAYSIGH corresponding to residues 383-397 of rat P2rx3.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.

Reconstitution

Reconstitute the lyophilized vial with 50 µL or 200 µL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

Target description

The P2X₃ receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X₃/P2X₂). ATP released from damaged cells activates the P2X₃ receptor to initiate nociceptive signals. Involvement of ATP in the mechanism of chronic pain contributes to P2X₃ receptor as a possible target for the development of pain therapeutics.