Monoclonal Anti-Munc13/1 antibody produced in mouse, approx. 2 mg/mL, clone Munc13-71, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Monoclonal Anti-Munc13/1 antibody produced in mouse has been used in enzyme linked immunosorbent assay (ELISA) and immunoblotting.

Biochem/physiol Actions

Munc13/1 has a crucial role in synaptic vesicle priming. It interacts with Syntaxin 1A and helps it to bind to soluble NSF attachment protein receptor (SNARE) proteins. Thus it contributes to the stability of the SNARE complex. Deletion of Munc13/1 leads to complete arrest synaptic transmission.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-Munc13-1 (mouse IgG2b isotype) is derived from the hybridoma Munc13-71 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a synthetic peptide of rat Munc13-1, conjugated to KLH. Protein unc-13 homolog A (Munc13-1) contains a diacylglycerol (DAG)/b phorbol ester-binding C1 domain. Munc13-1 are expression in axon is observed at various synapse populations.

Munc13/1 is a diacylglycerol receptor which is expressed in the presynaptic area.

Immunogen

synthetic peptide corresponding to amino acid 10-27 of rat munc13/1, conjugated to KLH.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.