Anti-matrix metalloproteinase-12*(mmp-12

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Matrix metalloproteinase-12 (MMP-12) is involved in breaking down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.

Disclaimer

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General description

Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on human chromosome 11.

Immunogen

synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-12 (macrophage elastase).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Specificity

The antibody recognizes only the latent form of MMP-12 and not the active forms. May be used to distinguish the zymogen and the activated enzyme.