Monoclonal anti-interleukin-2

Not available outside of the UK & Ireland.

Application

Anti-interleukin-2 antibody may be used in immunohistochemistry at a working concentration of 8-25 µg/ml in human peripheral blood leukocytes. For flow cytometry a concentration of 25 µg/ml may be used. The antibody is suitable for IL-2 neutralization assays.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. IL-2 is important for proliferation of lymphocytes, natural killer cells and macrophages and in the differentiation of CD4⁺ cells into Th1 and Th2 effector cells. The effects of IL-2 are mediated by the signalling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signalling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle Monoclonal Anti-Interleukin-2 recognizes human Interleukin-2. It does not react with mouse IL-2.

Immunogen

purified, E. coli-derived recombinant human interleukin-2.

Physical form

Lyophilized from a 0.2 µm filtered solution in phosphate buffered saline with 5% trehalose.