Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse, clone 70625.111, purified immunoglobulin, lyophilized powder

Not available outside of the UK & Ireland.

Biochem/physiol Actions

IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.

General description

The antibody will neutralize the biological activity of recombinant human IL-18 receptor.

Immunogen

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

Physical form

Lyophilized from a 0.2 µm filtered solution in phosphate buffered saline with 5% trehalose.

Preparation Note

Purified using protein G.