Monoclonal anti-interleukin-7 clone: 741

Not available outside of the UK & Ireland.

Application

Anti-Interleukin-7 antibody may be used for immunoblotting at a working concentration of 1-2 µg/ml. For ELISA the working concentration recommended is 1-2 µg/ml. The antibody is also suitable for neutralization assays.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. IL-7 is produced by bone marrow cells, liver and intestinal epithelia cells, dendritic cells, smooth muscle cells, fibroblasts macrophages and keratinocytes. The effect of IL-7 is mediated by IL-7 receptor α chain and by the subsequent activation of JAK/STAT, PI3K and Src kinases. Important roles of IL-7 include proliferation of lymphoid progenitors, survival and homeostasis of naïve and memory T cells Monoclonal Anti-Interleukin-7 recognizes recombinant human IL-7 (approximately 17 kDa).

Immunogen

purified recombinant human IL-7, expressed in E. coli.

Physical form

Lyophilized from a 0.2 µm filtered solution in phosphate buffered saline containing 5% trehalose.

Specificity

The antibody has the ability to neutralize the biological activity of recombinant human IL-7. It may also be used as a capture antibody in a human IL-7 ELISA.