Anti-Uimc1

Not available outside of the UK & Ireland.

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

Ubiquitin interaction motif containing 1 (UIMC1) functions as repressor for the nuclear receptor, retinoid-related, testis-associated receptor (RTR). It coordinates the placement of breast cancer type 1 susceptibility protein (BRCA1) in the site of DNA damage. Mutations in UIMC1 leads to impairment of BRCA1 mediated DNA repair and is implicated in breast cancer.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

Ubiquitin interaction motif containing 1 (UIMC1), also called receptor-associated protein 8 (RAP80), is a transcriptional activator protein. It encodes a 79.6 kDa protein and is localised in nucleus. It is highly expressed in testis. UIMC1 contains a nuclear localization signal and two zinc fingers at the C-terminus. It has tandem ubiquitin interacting motifs (UIMs). The UIMC1 gene is located on human chromosome 5q35.2.

Immunogen

ubiquitin interaction motif containing 1 recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST79996.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.