Anti-Arhgap31

Not available outside of the UK & Ireland.

Application

All Prestige Antibodies^®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.Anti-ARHGAP31 antibody produced in rabbit has ben used in western blotting and immunohistochemistry.

Biochem/physiol Actions

ARHGAP31 (Rho GTPase activating protein 31) is a Rac1 (Ras-related C3 botulinum toxin substrate 1) and Cdc42 (cell division control protein 42 homolog) specific GTPase activating protein. It works in integrin-dependent manner. ARHGAP31 is present on the focal adhesions (FAs) located on rigid surfaces and is responsible for cell migration, FA size and FA dynamics. Mutations in this gene result in Adams-Oliver disease, characterized with congenital scalp defects and terminal transverse limb defects.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

The gene ARHGAP31 (Rho GTPase activating protein 31) is mapped to human chromosome 3q13.3. It is ubiquitously expressed. The encoded protein has a GAP (GTPase-activating protein) domain, a basic-rich central region, a proline-rich domain and an extended C-terminal region.

Immunogen

Rho GTPase activating protein 31 recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST78412.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.