Anti-akt2

Not available outside of the UK & Ireland.

Application

Anti-AKT2 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

RAC-β serine/threonine-protein kinase is an enzyme encoded by the AKT2 gene in humans and is mapped to chromosome region 19q13.1-q13.2. It belongs to a distinct subfamily of protein-serine/threonine kinases containing Src homology 2-like domains. Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas. The protein kinase is thought to be a key mediator of the insulin signal transduction process and plays a role in glucose metabolism. It also mediates the development or maintenance of proper adipose tissue and islet mass. It is an important protein in PI3K signaling pathway and is overexpressed in a variety of malignant tumors. AKT2 may be a useful molecular marker for predicting the prognosis of meningioma. It plays a novel role in neuroblastoma tumorigenesis and may be important for developing novel therapeutics for the treatment of clinically aggressive neuroblastoma.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Synthetic peptide sequence of V-akt murine thymoma viral oncogene homolog 2.

Immunogen Sequence: GI # 4502023, sequence 108-124

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.