Anti-CLIF antibody produced in chicken, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-CLIF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

The CLIF gene encodes a member of the basic helix-loop-helix PER-ARNT-SIM family of transcription factors and is located on chromosome12. It helps in controlling diverse physiological processes including circadian rhythm. CLIF is expressed in endothelial cells and neurons in the brain, including the suprachiasmatic nucleus and the center of the circadian clock. In endothelial cells, it forms a heterodimer with CLOCK and up-regulates the PAI-1 gene through E-box sites. CLIF helps in regulating the circadian oscillation of PAI-1 gene expression in endothelial cells. Its expression is increased in colorectal cancer and is related to tumor invasiveness and aggressiveness.

Immunogen

Recombinant transcription factor BMAL2

Immunogen Sequence: GI # 9910368, sequence 8-100

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.