Anti-endothelin a receptor

Not available outside of the UK & Ireland.

Application

Anti-Endothelin A Receptor antibody produced in rabbitis suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 3-16µg/mL using human heart tissue.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Immunohistochemistry (1 paper)

Biochem/physiol Actions

Endothelin A Receptor (ETA) is one of three endothelin receptors that mediates the effects of endothelin-1, a vasoconstrictor peptide. Located in the smooth muscle tissue of blood vessels, the interaction between endothelin and ETA plays a role in the regulation of blood pressure. Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETA mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

synthetic peptide corresponding to the third extracellular domain of human endothelin A receptor, conjugated to KLH. The immunizing peptide has 100% homology with mouse

Physical form

Solution in phosphate buffered saline containing 0.1% sodium azide.