Anticorps Anti - DCDC2 (C - terminal )produit en lapin, environ 1,5 mg / mL, anticorps isolé affinité, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti-DCDC2 antibody produced in rabbit is suitable for western blot analysis at a working concentration of 0.5-1µg/mL using a HEK-293T cell lysate expressing human DCDC2.

Biochem/physiol Actions

DCDC2 is one of the dyslexia susceptibility genes involved in neuronal migration and other developmental processes. The DCX domain of DCDC2 binds tubulin and enhances microtubule polymerization. Several SNPs within the DCDC2 gene have been associated with dyslexia. It modulates neuronal development in the brain.

Mutations in the DCDC2 gene is implicated in non-syndromic recessive deafness DFNB66 neonatal sclerosing cholangitis (NSC) and renal-hepatic ciliopathy.

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Doublecortin domain-containing protein 2 (DCDC2) belongs to the doublecortin (DCX) superfamily and contains two doublecortin domains. DCDC2 is expressed in the fetal and adult central nervous system (CNS). DCDC2 gene is mapped to human chromosome 6p22.3.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Specificity

Anti-DCDC2 (C-terminal) specifically recognizes human DCDC2.

Storage and Stability

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.