Monoclonal Anti-Calcitonin Gene-Related Peptide antibody produced in mouse, clone CD8, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-Calcitonin Gene-Related Peptide (CGRP) antibody is suitable for immunohistochemistry at a working antibody dilution of 1:200 to 1:1000 using formalin-fixed, paraffin-embedded sections or cryostat tissue sections. The antibody may be used for immunofluorescence at a working dilution of 1:500.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Calcitonin gene-related peptide (CGRP) is a vasodilator that belongs to the calcitonin family of peptides. It is produced by motor neurons of peripheral and central nervous system. There are two forms of CGRP, α and β, which exhibit similar functions. The effects of CGRP are mediated by G-protein coupled receptor heterodimer formed by calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein 1 (RAMP1). Several biological effects of CGRP are observed in nervous, endocrine, immune and cardiovascular systems. Multiple studies have implicated CGRP in the pathophysiology of migraine and antagonists to CGRP are being explored as treatment options Monoclonal Anti-Calcitonin Gene-Related Peptide (CGRP) recognizes human and guinea pig CGRP. It does not cross react with rat CGRP.

Immunogen

peptide corresponding to the C-terminal of rat α−calcitonin gene-related peptite (CGRP).

Physical form

Solution in PBS containing 1% BSA and ≤ 0.1% sodium azide