Anti-Calcium Channel CaV1.2 (human) antibody produced in rabbit, affinity isolated antibody, lyophilized powder

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Calcium channel, voltage-dependent, L type, α1C subunit (Ca_v1.2) is a protein encoded by the CACNA1C gene in humans and belongs to the family of voltage-gated calcium channels. It serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate different physiological events. CACNA1C is a subunit of L-type voltage-dependent calcium channel. It is mapped to chromosome 12p13.3 and is implicated as a susceptibility gene for schizophrenia. CACNA1C is selectively expressed in human TH2 cells and blockage of Ca_v1.2 channel activation in TH2 cells may represent new strategies to treat allergic diseases in human subjects. Its increased activity is implicated in the pathogenesis of dementia and Alzheimer′s disease (AD).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

peptide corresponding to residues 2-15 of human Ca_v1.2 (exon 1B). The sequence has 14/15 residues identical in mouse and rat.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, with 1% BSA and 0.05% sodium azide.

Specificity

Recognizes mouse Ca_v1.2, splice variants P22002-4 and P22002-5 of rat Ca_v1.2 and splice variant P15381-4 of rabbit Ca_v1.2.

Target description

Calcium Channel Ca_V1.2 (CACNA1C ) encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization.