Anti-INSM1

Not available outside of the UK & Ireland.

Application

Rabbit Anti-INSM1 antibody can be used for western blot assays at a concentration of 1.25µg/ml. The antibody can also be used for IHC at 4-8µg/ml using paraffin-embedded tissues.

Rabbit polyclonal anti-INSM1 antibody is used to tag Insulinoma-associated 1 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of Insulinoma-associated 1 in endocrine and neuroendocrine cell differentiation.

Biochem/physiol Actions

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Insulinoma-associated 1 (INSM1/IA-1) is a zinc-finger transcription factor restrictedly expressed in pancreatic β-cells during early pancreas development. INSM1/IA-1 regulates NeruoD1/β2 and insulin gene expression during β-cell maturation. INSM1 transcription factor, an important player in early embryonic neurogenesis, contributes to endocrine and neuroendocrine cell differentiation.

Rabbit polyclonal anti-INSM1 antibody reacts with canine, bovine, human, mouse, rat, and zebrafish Insulinoma-associated 1 transcription factors.

Immunogen

Synthetic peptide directed towards the middle region of human INSM1

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: PAAALRPPGKRPPPPTAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPV