Anti-Serpinf2

Not available outside of the UK & Ireland.

Application

This Anti-Serpinf2 antibody is validated for use in WB, IH for the detection of Serpinf2.

Research CategorySignaling

Research Sub CategorySignaling Neuroscience

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Serpinf2 in human liver and human liver cancer tissue.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Serpin F2, also known as Alpha-2-antiplasmin Alpha-2-AP, Alpha-2-plasmin inhibitor, Alpha-2-PI, and encoded by the gene name SERPINF2, AAP, or PLI, is a member of the Serpin family. Serpin F2 is a serine protease inhibitor. As an inhibitor, the major targets of Serpin F2 are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Serpin F2 forms protease inhibiting heterodimer with TMPRSS7. Serpin F2 is expressed by the liver and secreted in plasma. Mutations in Serpin F2 have been associated with Alpha-2-plasmin inhibitor deficiency (APLID), an autosomal recessive disorder resulting in severe hemorrhagic diathesis.

Immunogen

Epitope: Alpha-2-antiplasmin mature chain

KLH-conjugated linear peptide corresponding to the Alpha-2-antiplasmin mature chain of human Serpinf2.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Serpinf2 in 10 µg of human liver tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~73 kDa observed. Predicated to work with both glycos and non-glycos isoforms.