TRAIL; Human; Recombinant; E. coli

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Induces apoptosis in U937 cells at 1 µg/ml within 5 h.

General description

Recombinant, human TRAIL (amino acids 114-281) expressed in E. coli. Ligand for TRAIL receptors DR4 and DR5. Displays potent antitumor activity against selected targets and induces apoptosis in a number of transformed cell lines, but not in normal tissues.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lin, Y., et al. 2000. Mol. Cell. Biol.20, 6638.Mitsaides, N., et al. 2000. Cancer Res.60, 4122.Griffith, T.S., et al. 1999. J. Exp. Med.189, 1343.Mariani, S.M., et al. 1997. J. Cell Biol.137, 221.Pan, G., et al. 1997. Science276, 111.Pan, G., et al. 1997. Science277, 815.Sheridan, J.P., et al. 1997. Science277, 818.Pitti, R.M., et al. 1996. J. Biol. Chem.271, 12687.Wiley, S.R., et al. 1995. Immunity3, 673.

Packaging

100 µg in Plastic ampoule

Please refer to vial label for lot-specific concentration.

Physical form

In 500 mM NaCl, 10 mM Na₂HPO₄, 2.7 mM KCl, 2 mM KH₂PO₄, 0.1 mM DTT, ≤10% glycerol.

Reconstitution

Following initial thaw, aliquot and freeze r>(-70°C).

Warning

Toxicity: Standard Handling (A)