Non disponible en dehors du Royaume-Uni et de l'Irlande
General description
Full-length, recombinant, human phosphodiesterase 4B2 (accession no. L20971) fused at the N-terminus to a His Tag™ sequence and expressed in S. frugiperda using a baculovirus expression system. Plays a significant role in the regulation of inflammatory cell activation. PDE4B2 is a predominant isoform in neutrophils and monocytes. Supplied as a partially purified, catalytically active preparation.
Legal Information
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Gibson, L.C.D., et al. 2006. Eur. J. Pharmacol.538, 39.Smith, P.G., et al. 2005 Blood105, 308.Baroja, M.L., et al. 1999. J. Immunol.162, 2016.
Packaging
10 u in Plastic ampoule
Physical form
In 150 mM NaCl, 10 mM Tris, 0.1% NP-40, pH 8.3.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C).
Unit Definition
One unit is defined as the amount of enzyme that will convert 1 pmol cAMP to AMP per min at 30°C, pH 7.5.
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :