TFLLR-NH2 trifluoroacetate salt, , >98% (HPLC)

Code: T7830-5MG D2-231

Not available outside of the UK & Ireland.

Amino Acid Sequence

Thr-Phe-Leu-Leu-Arg-NH2

Application

TFLLR-NH2 trifluoroacetate salt has been used as a protease-activated receptor...


 Read more

Your Price
$207.31 5MG
REQUEST

Not available outside of the UK & Ireland.

Amino Acid Sequence

Thr-Phe-Leu-Leu-Arg-NH2

Application

TFLLR-NH2 trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).

Biochem/physiol Actions

TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

Packaging

5, 25 mg in glass bottle

Preparation Note

TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.

assay>98% (HPLC)
colorwhite to tan
formlyophilized powder
InChI keyQVNWOGSDGQDGHP-MKVNCOEFSA-N
InChI1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);(H,6,7)/t19-,21+,22+,23+,24+,25+;/m1./s1
Quality Level100
SMILES stringOC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
solubilityH2O: >2 mg/mL
storage temp.−20°C
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN
GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.