Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.
MK6-83is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.
Packaging
5, 25 mg in glass bottle
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