SMBA1

Code: sml1464-5mg D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

SMBA1 is an anti-tumor agent. It exhibits anti-proliferative effects against glioblastoma (GBM) cells.

Small-molecule Bax agonists 1 (SMBA1) is ...


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$113.62 5MG
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Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

SMBA1 is an anti-tumor agent. It exhibits anti-proliferative effects against glioblastoma (GBM) cells.

Small-molecule Bax agonists 1 (SMBA1) is a potent and selective Bax agonist that binds to Bax, induces conformational change which blocks Bax S184 phosphorylation. SMBA1 induces apoptosis in cancer cells and suppresses lung tumor growth in vivo without significant normal tissue toxicity. SMBA1 does not bind to other B-cell lymphoma 2 (Bcl-2) family members.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyPEYKRJBXACUOOB-WOJGMQOQSA-N
InChI1S/C20H13NO3/c22-20-8-4-1-5-13(20)11-18-16-7-3-2-6-15(16)17-10-9-14(21(23)24)12-19(17)18/h1-12,22H/b18-11+
Quality Level100
SMILES stringOC(C=CC=C1)=C1/C=C2C(C=CC=C3)=C3C4=C2C=C([N+]([O-])=O)C=C4
solubilityDMSO: 20 mg/mL, clear
storage temp.−20°C
Cas Number906440-37-7
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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