CINK4

Code: SML1352-25MG D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC50 = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CIN...


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$364.82 25MG
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Not available outside of the UK & Ireland.

Biochem/physiol Actions

CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC50 = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CINK4 dose-dependently inhibits phosphorylation of retinoblastoma (Rb) and induces G0-G1 cell cycle arrest and apoptosis in cancer cell lines.

Packaging

5, 25 mg in glass bottle

assay≥95% (HPLC)
colorwhite to light brown
formpowder
InChI keyYVXCDLCJCIDFHE-AFARHQOCSA-N
InChI1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)/t21-,23-
Quality Level100
SMILES stringO[C@@H]1CC[C@@H](NC2=CC(NCC)=NC(NC3=CC=C(N(CC4=CC=CC=C4)C=C5)C5=C3)=N2)CC1
solubilityDMSO: 25 mg/mL, clear
storage temp.2-8°C
Cas Number359886-84-3
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