SANT-1, >=98% (HPLC), powder

Code: S4572-5MG D2-231

Not available outside of the UK & Ireland.

Application

Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SA...


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Your Price
$238.56 5MG
REQUEST

Not available outside of the UK & Ireland.

Application

Treatment of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death.

Biochem/physiol Actions

SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.

SANT-1 inhibited Sonic hedgehog signaling and induced apoptosis via Ras/NF-κB pathway in glioblastoma cells.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
formpowder
InChI keyFOORCIAZMIWALX-JJIBRWJFSA-N
InChI1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
Quality Level100
SMILES stringCc1nn(-c2ccccc2)c(C)c1C=NN3CCN(CC3)Cc4ccccc4
solubilityDMSO: 5 mg/mL, clear (warmed)
storage temp.−20°C
Cas Number304909-07-7
This product has met the following criteria to qualify for the following awards:



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