Oxamflatin

Not available outside of the UK & Ireland.

Application

Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor: to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system to study its stand-alone effect on cytarabine-sensitive and resistant cells.

Biochem/physiol Actions

Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.

Histone deacetylase inhibitor; anti-cancer agent.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

1, 5 mg in glass bottle