17:0-20:4 PS

Not available outside of the UK & Ireland.

Application

17:0-20:4 PS or 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine has been used as an internal standard:in lipid extraction from isolated pure mitochondria for mass spectrometry (MS) analysisfor lipid quantification/analysis using liquid chromatography (LC)-MSfor phospholipid quantification by MSin lysophospholipid acyltransferases (LPLAT) assayin the preparation of total lipid extracts from lysosome samples by tert-butyl methyl ether (MTBE) lipid extraction protocol for analysis by LC-MSfor ratiometric quantification of phosphatidylserine (PS) using LC-MS

Biochem/physiol Actions

Phosphoserine (PS) maintains the nerve cell membrane and myelin sheath. It is found to be associated with cognitive disability in Alzheimer′s disease.

General description

In humans, phosphoserine(PS) is present in the intracellular membranes and grey matter. It is localized to the nuclear envelope, endoplasmic reticulum, Golgi apparatus, outer mitochondrial membranes, plasma membranes and myelin.

Packaging

2 mL Amber Glass Sealed Ampule (LM1302-1EA)