Accuris GenoSep Capillary Electrophoresis System

The Accuris GenoSep™ is a compact capillary electrophoresis system for high-resolution nucleic acid and protein characterisation. The system combines automated capillary electrophoresis with sensitive fluorescence detection to deliver accurate fragment sizing, quantification, and quality assessment for DNA, RNA, proteins, NGS libraries, and cell-free DNA (cfDNA) samples.

The Accuris GenoSep™ instrument utilises convenient, reusable cartridges to separate nucleic acids and proteins. Each cartridge incorporates a proprietary polymer matrix and a fused silica capillary. During analysis, programmable high voltage is applied through the capillary to generate an electric field that drives the electrophoretic migration of macromolecules through the polymer matrix. Differences in electrophoretic mobility result in size-based separation, and fluorescently labelled fragments are detected as they pass the optical detection window. User-selectable voltages enable methods to be optimised for different applications and fragment size ranges.

To ensure exceptional sensitivity and reproducibility, each GenoSep™ cartridge is produced under a rigorous manufacturing process to ensure consistent results from cartridge to cartridge. Precision high-voltage control with automated instrument operation allw the GenoSep™ system to deliver highly reproducible migration times, enabling accurate fragment sizing and reliable comparison between runs. The GenoSep™ system also provides exceptional sensitivity, with a limit of detection as low as 2 pg. This high sensitivity is achieved through LED-induced fluorescence detection, optimised optical design, and a proprietary low-background separation matrix that minimises background noise and enhances signal-to-noise performance.

• Fully automated workflow
• 10-inch high-resolution LCD touchscreen
• Features ready-to-use gel cartridges
• Each cartridge processes up to 240 samples, depending on the type of cartridge
• Supports analysis of 1-16 samples per run
• Detection sensitivity as low as 1 pg/μL under optimised conditions
• Analytical resolution of up to 1-4 bp
• Requires a minimum sample volume of only 10μL using standard 0.2mL PCR tubes
• Electropherogram peak charts and virtual gel image outputs
• Suitable for PCR fragment analysis, NGS library quality control, RNA analysis, and cfDNA assessment
• Cartridges sold separately
• Laptop not included