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Application
N-(4-Bromophenyl)-N-phenylacrylamide is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile, or ″scout″ fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC® molecules for targeted protein degradation as demonstrated by the Cravatt Lab for E3 ligase discovery.
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes
Technology Spotlight: Proteomic Ligandability AssessmentProteome-wide covalent ligand discovery in native biological systemsElectrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
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