Diméthyle SPHINGOSINE (D18:1 )

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Dimethyl sphingosine (d18:1) has been used as an inhibitor of sphingosine kinase.

Dimethyl Sphingosine (d18:1) may be used: to investigate D-erythro-N,N-dimethylsphingosine (DMS)-induced cell death in U937 cells to understand its molecular mechanism to study its effects on intracellular Ca²⁺ concentration, pH and glutamate uptake in human 1321N1 astrocytes in substrate specificity studies of sphingosine methyltransferase activity in rat kidney homogenate

Biochem/physiol Actions

D-erythro-N,N-dimethylsphingosine (DMS) prevents the activity of sphingosine kinase and protein kinase C.It modulates cellular activities. DMS exhibits anti-cancer and apoptotic properties. It is involved in the augmentation of epidermal growth factor receptor (EGFR) and inhibition of src kinase. DMS functions as a potential therapeutic for Chagas disease cardiomyopathy through its anti-parasitic and immunomodulatory properties.

D-erythro-N,N-dimethylsphingosine (DMS) has an ability to inhibit the activity of sphingosine kinase. It also helps to study the role of sphingosine 1-phosphate (SPP) as an intracellular second messenger. DMS exhibits anti-parasitic and immunomodulatory activities. It acts as a potential therapeutic for chronic Chagas disease cardiomyopathy.

General description

Dimethyl Sphingosine (d18:1), also called as N,N-Dimethyl-d-erythro-sphingosine (DMS), is a natural sphingolipid metabolite. It is found in various tissues.

Packaging

5 mL Clear Glass Sealed Ampule (860496O-5mg)