14:0 CARDIOLIPIN (sel d'AMMONIUM)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

14:0 Cardiolipin (1′,3′-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (ammonium salt)) has been used: as a standard in tandem mass spectrometryin the preparation of membrane proximal region (MPR) of human immunodeficiency virus (HIV-1) glycoprotein 41 (gp41)-lipopeptide conjugate and liposomesas a component of micelle for suspending C8 ceramide substrate in ceramide kinase assay

Biochem/physiol Actions

Cardiolipin (CL) plays a key role in oxidative phosphorylation. CL is essential for energy production and in the activation of apoptosis. Deficiency of CL is associated with the development of diabetes and age-related heart failure. Anomalies associated with CL composition is observed in Barth Syndrome (BTHS).

General description

14:0 Cardiolipin is an acidic phospholipid. Structurally, cardiolipin comprises three glycerol moieties and four acyl chains and is localized in the inner membrane of mitochondria. 14:0 Cardiolipin contains four myristic acid as acyl chain.

Packaging

5 mL Clear Glass Sealed Ampule (710332C-25mg)