Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Primary Target5-HT Transporter
Potent and selective serotonin uptake inhibitor (Ki = 5.4 nM); antidepressant
General description
A potent uptake inhibitor highly selective for 5-HT transporter without effect on noradrenalin or dopamine uptake (IC50 = 1.8, 8800 and 41000 nM for 5-HT, noradrenalin and dopamine, respectively). Clinically prescribed as an antidepressant drug. Widely used in research related to depressive disorders.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Garriock, A., et al., 2010. Bio. Psychiatry.67, 133.Gabriel, J.P., et al. 2009. J. Neurosci.29,10387.Torres, G.E., et al. 2003. Nat. Rev. Neurosci.4, 13.
Packaging
25 mg in Glass bottle
Reconstitution
Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Harmful (C)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :