Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Target IC50: 5.6 µM against JAK3
Reversible: yes
Product competes with ATP.
Cell permeable: yes
Primary TargetJAK-3
General description
A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 5.6 µM). Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Also acts as a potent inhibitor of glioblastoma cell adhesion and migration.
A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3. Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-jun in DT-40 cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Ghosh, S., et al. 2001. Acta Crystallogr. C.57, 76.Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.Narla, R.K., et al. 1998. Clin Cancer Res.4, 2463.
Packaging
Packaged under inert gas
5 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Standard Handling (A)
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