Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Reversible: no
Primary TargetcGMP-inhibited phosphodiesterase
Product does not compete with ATP.
Cell permeable: yes
Target IC50: 300 pM against cGMP-inhibited phosphodiesterase
General description
Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC50 = 300 pM) and platelet aggregation in vitro. Potentiates adenosine-stimulated cAMP accumulation.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Spina, D., et al. 1998. Life Sci. 62, 953.Pillai, R., et al. 1994. J. Biol. Chem.269, 30676.Tang, K.M., et al. 1994. Eur. J. Pharmacol.268, 105.Whalin, M.E., et al. 1991. Mol. Pharmacol. 39, 711.Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.DeClerck, F., et al. 1990. Blood Coag. Fibrinol. 1, 247.Konkle, B.A., et al. 1990. J. Biol. Chem. 265, 21867.Ruppert, D., and Weithmann, K.U. 1982. Life Sci.31, 2037.
Packaging
10 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Standard Handling (A)
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