Substance P hydrate de sel d'acétate, > = 95 %(HPLC) ,POUDRE

Code: S6883-5MG D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Application

Substance P acetate salt hydrate has been:used as a neurokinin 1 ...


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$430.78 5MG
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Non disponible en dehors du Royaume-Uni et de l'Irlande

Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2

Application

Substance P acetate salt hydrate has been:used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in miceadministered in central nucleus (ACE) in rat to study its positive reinforcing effectsused as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

Substance P acetate salt hydrate has been used in competition binding assays.

Biochem/physiol Actions

NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.

Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.

General description

Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

assay≥95% (HPLC)
colorwhite
formpowder
Gene Informationhuman ... TAC1(6863)
InChI keyVHKFRLDSEZYWAC-CIYRQLMPSA-N
InChI1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1
mol wt1348 Da by calculation (Average Mass)
Quality Level200
SMILES string[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O
solubility0.1 M acetic acid: 1 mg/mL
storage temp.−20°C
UniProt accession no.P20366
Cas Number137348-11-9
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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