Recombinant human interleukin-1 beta (IL-1β) is a pro-inflammatory cytokine and a potent mediator of inflammation and immune responses. It promotes the activation and recruitment of immune cells to sites of infection or injury, such as antigen presenting cells, macrophages, and T lymphocytes. In cell culture, IL-1β is used to stimulate and activate immune cells (macrophages and T cells), maintain hematopoietic progenitor cells, and modulate the differentiation of mesenchymal stem cells.
Human IL-1β is a monomer of a molecular weight of 17.3 kDa. This protein is animal origin-free, carrier protein-free, and tag-free to ensure a homogenous population with exceptional lot-to-lot consistency. IL-1β is suitable for reproducible, high-quality hematopoietic stem cells and more specific lineages.
- Highly pure human protein (UniProt number: P01584)
- >98%, by SDS-PAGE quantitative densitometry
- Source: Expressed in E. coli
- 17.3 kDa, monomer
- Animal origin-free (AOF) and carrier protein-free
- Manufactured in Cambridge, UK
- Lyophilised from HEPES/NaCl/Cys
- Resuspend in water at >100µg/mL, prepare single-use aliquots, add carrier protein if desired and store frozen at -20°C or -80°C