Trimethyl orthoformate, anhydrous, 99.8%

Not available outside of the UK & Ireland.

Application

Trimethyl orthoformate can be used:To convert sulfonic acids to methyl esters.To convert 2-acylcyclohexanones to the corresponding acetal derivatives.To mediate Pinacol reaction of various 1,2-diols with tin(IV) chloride without the formation of water.To synthesize 1-substituted-1H-1,2,3,4-tetrazoles via a three-component condensation with amine and sodium azide catalyzed by indium triflate under solvent-free conditions.For the N-methylation of amines in the presence of sulfuric acid.

General description

Trimethyl orthoformate is a commonly used reagent in organic synthesis for the preparation of useful building blocks. It is also used to introduce the protecting group for aldehydes by the preparation of acetals. Acetals can be deprotected back to the aldehyde by using acid catalysts.

Packaging

100 mL in Sure/Seal™

1, 2 L in Sure/Seal™