Non disponible en dehors du Royaume-Uni et de l'Irlande
Analysis Note
Colour (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.50 - 0.80 mmol/gSwelling Volume (in DMF): lot specific result
General description
Fmoc-PAL-AM resin consists of Barany′s aminomethyl-dimethoxyphenoxyvaleric acid linker [1] attached to aminomethylated polystyrene. The amino group of this linker can be easily acylated under standard coupling conditions. Following peptide assembly, treatment with 95% TFA containing scavengers releases the desired peptide amide. Studies have shown the acid sensitivity of this linker to be around twice that of the Rink amide linker [2]. There is some evidence to suggest that PAL resins give greater yields in microwave assisted synthesis.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
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