4-Chloro - 7 - nitrobenzofurazan, 98 %

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

4-Chloro-7-nitrobenzofurazan (NBD-chloride) was used in the following studies:Synthesis of fluorescent phospholipid-derivative, NBD-didecanoylphosphatidylethanolamineSynthesis of functionalized hydroxynaphthofurazan.Spectrophotometric and spectrofluorometric determination of clemastine hydrogen fumarate, loratadine, losartan potassium and ramipril in pharmaceutical formulations.Synthesis of 7-nitrobenzofurazan (NBD)-labeled maleimide, via Diels-Alder reaction.

General description

4-Chloro-7-nitrobenzofurazan (NBD-Cl) is a highly sensitive chromogenic and fluorogenic reagent. It is reported to react spontaneously with trans-1-methoxy-3-(trimethylsilyloxy)-1,3-butadiene (Danishefsky′s diene), to afford regioselectively the silyl enol ether, via normal electron-demand Diels-Alder (NEDDA) reaction. A study of the molecular structure, vibrational spectra and NBO (Natural Bond Orbital) analysis of NBD–Cl has been undertaken. Its utility as a pre-column derivatization agent has been examined.

Packaging

1, 5 g in glass bottle