Not available outside of the UK & Ireland.
Application
N,N′-Disuccinimidyl carbonate (DSC) can be used to synthesize: Various carbamate derivatives from primary and sterically hindered secondary alcohols by alkoxycarbonylation. Active carbonate resins from 4-hydroxymethylpolystyrene and 4-hydroxymethyl-3-nitrobenzamido resins via hydroxy functional groups. Aza-glycinyl dipeptides, important intermediates for the preparation of various azapeptides.It may be also used:In the two-step preparation of 5-(6-(azidomethyl)nicotinamido)pentanoic acid, a copper-chelating picolyl azide derivative.To activate the hydroxyl group of the hapten, γ-hydroxyphenylbutazone (HPBZ) so that HPBZ can effectively bind with human serum albumin(HSA)-immunogen to form a hapten-protein conjugate.
Other Notes
Convenient reagent for preparing N-succinimidyl esters of N-protected amino acids and other acids; activated carbonate, e.g. synthesis of ureas and carbamates; coupling of ligands to proteins (via lysines).
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