Non disponible en dehors du Royaume-Uni et de l'Irlande
Analysis Note
Solubility - freely soluble in water , in chloroform and in ethanol (96%)
Application
Thio-TEPA (N,N’;N’;-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to haematopoietic progenitor cell transplantation (HPCT).
Biochem/physiol Actions
The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.
General description
Chemical structure: aziridine
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Packaging
1 g in poly bottle
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :