Hydrochlorure de kasugamycine provenant de Streptomyces kasugaensis, >=90% (HPLC)

Code: K4013-10G D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Kasugamycin (Ksg) is an aminoglycoside antibiotic isolated from Streptomyces kasugaensis. It is used to study ribosome structure and interactions near th...


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$494.06 10G
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Kasugamycin (Ksg) is an aminoglycoside antibiotic isolated from Streptomyces kasugaensis. It is used to study ribosome structure and interactions near the m26A m26A sequence. It is used to study the mechanisms of kasugamycin resistance.

Biochem/physiol Actions

Kasugamycin binds within the mRNA channel of the 30S subunit between the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA. It inhibits protein synthesis and binding of aminoacyl-sRNA to the ribosomes in fungi and induces f-met-tRNA dissociation from the P-site of the 30S subunit.

General description

Chemical structure: aminoglycoside

Packaging

10 g in glass bottle

antibiotic activity spectrumGram-positive bacteria, Gram-negative bacteria
biological sourceStreptomyces kasugaensis
colorwhite to off-white
formpowder
InChI keyZDRBJJNXJOSCLR-NZXABURVSA-N
InChI1S/C14H25N3O9.ClH/c1-3-5(17-12(16)13(23)24)2-4(15)14(25-3)26-11-9(21)7(19)6(18)8(20)10(11)22;/h3-11,14,18-22H,2,15H2,1H3,(H2,16,17)(H,23,24);1H/t3-,4+,5+,6-,7+,8+,9-,10+,11+,14-;/m1./s1
mode of actionprotein synthesis | interferes
Quality Level200
SMILES stringC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](N)C[C@@H]1NC(C(O)=O)=N.Cl
storage temp.2-8°C
Cas Number19408-46-9
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